Background: Little data exists comparing pathologic outcomes of laparoscopic versus retropubic radical prostatectomy.
Methods: Over 1000 radical prostatectomy specimens were collected over a 44 month period for our tissue bank. This was a 75% rate of collection of the total radical prostatectomy operations at our institution. 990 cases were available for analysis. Pathologic data from 706 retropubic operations (RRP)and 284 laparoscopic operations (LRP) were compared.
Results: 86.6% of LRP and 90.5% of RRP were performed for cT1c disease. The patients in both series were equivalent in pre-op PSA, clinical stage, and biopsy Gleason scores. Pathologic Gleason score distribution and stages were statistically equivalent between LRP and RRP. Postive Margins for LRP were 15.1% overall; 17.4% for RRP. Complete subset analysis was notable for margin positive rate for pT2 of 13.1% for LRP and 13.4% for RRP p=NS and 28.2% in pT3 for LRP and 38.0% for RRP p<0.05 for analysis.
Conclusions: Laparoscopic Radical Prostatectomy in this large series results in very favorable pathologic features in this comparison to comparable patients undergoing Radical Retropubic Prostatectomy.

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