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Determination of renal function by measuring renal volume on computed tomography.
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Determination of renal function by measuring renal volume on computed tomography.
Susan Lahey, MD, Brian H. Eisner, MD, Onofrio A. Catalano, MD, Dushyant V. Sahani, MD.
Massachusetts General Hospital, Boston, MA, USA.
Introduction: Nuclear scintigraphy is the gold standard for assessment of renal function. The current study evaluates the ability to predict renal function based on computed tomography (CT) renal volume measurements.
Materials and Methods: CT scans from 22 patients with chronic renal obstruction were evaluated. Renal volume was determined by adding the renal area measured on all coronal CT slices utilizing General Electric Healthcare software for semiautomated segmentation for renal volume estimation. Each renal volume was converted to % total renal volume and compared with Mag3 or DMSA nuclear imaging using Pearson’s correlation coefficient. This was performed for 11 contrast-enhanced CT scans and 11 unenhanced CT scans. Causes for chronic obstruction were ureteral stone (7), ureteral stricture (2), and ureteropelvic junction obstruction (13).
Results: There was a highly significant correlation between renal volume calculated by CT scan and renal function on nuclear imaging (r=0.90, p<0.0001, 95% CI 0.78-0.96). In 14/22 cases (64%), CT-estimated renal volume of the obstructed kidney was within 15% renal function determined on nuclear imaging.
Conclusions: There exists a strong correlation between CT measured renal volume and renal function determined by nuclear imaging. In the future, CT may be used to determine which patients should have nuclear imaging and may serve as a surrogate for nuclear imaging in select cases.
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